Yes. The difference between this and other bottles I have (HydroFlask, H2go Hawaii, Thermo Tank, etc.) is that this bottle’s stopper fits on the inside of the bottle, so you can’t fill it up to the top. You need to keep the inside fluid about an inch from the top of the bottle. Plus the circumference of the bottle neck is smaller than the circumference of the body, so it could be hard to clean, especially with a viscous fluid like a smoothie. But other than that, I think it should keep the smoothie cool throughout the day, although it may not last that long if it tastes real good.