"Has anyone found a more comprehensive leaky gut test than the one offered by Cyrex? The problems I have with the Cyrex test are: 1) There is no direct measurement of lipopolysaccharides (LPS) in this test. All the measurements are indirect tests looking

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Has anyone found a more comprehensive leaky gut test than the one offered by Cyrex? The problems I have with the Cyrex test are:
1) There is no direct measurement of lipopolysaccharides (LPS) in this test. All the measurements are indirect tests looking for immune system markers (antibodies).
2) What about the patient who has a fairly leaky gut who does not develop antibodies to LPS? If you buy into the whole Shoemaker diagnostic of mold mycotoxins, some people never develop antibodies to particular toxins or antigens. It stands to reason that some people would never develop antibody responses to LPS either, yet they might have a lot of chronic low level innate immune system markers. Cyrex never looks for those.
A biochemist friend of mine told me there used to be a leaky gut test that looked at the problem in a much more comprehensive way than Cyrex does, but he thinks they are out of business. What alternatives are there?
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 I was part of a leaky gut study through transformation enzymes. Feel free to message me, but there’s no one test. Leaky gut is a problem that encompasses many possibilities. We did Genova stool testing, blood work comma SRX test, but I don’t think that one is necessary, Eliza act food sensitivity testing, and a Mannitol test. I think the most important tests to do with leaky gut include still testing, a full blood panel, and food sensitivity testing which we did through Elisa Act. As a practitioner, the first thing I work on his enzyme in digestion function. So I have a full enzyme protocol that I use, including food sensitivity removal and a modified Paleo Diet. Sure they’re clean up may come later, but I have found this to be incredibly beneficial for myself and for my clients
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I would love to hear the protocol used in that study. Maybe you could post a URL to the study itself?

Food sensitivity testing is very controversial. Technically, elevated IgA or IgM readings on a protein simply means the immune system *recognizes* the protein. It does not necessarily mean that the body has a bad reaction to that protein. Frankly I am more scared by the food that produces zero Igx responses because that food may be one that becomes invisible to the immune system. At that point no antibody forms if it has a toxin and the innate immune system starts releasing cytokines. The upshot of all of that is that these food sensitivity tests may be suggesting 180 degrees the opposite of the truth.

Mannitol test is interesting. How does that one work?

Is there any vendor with an explicit “leaky gut” test besides Cyrex that uses a different approach?

What is the basic idea on your enzyme protocol? Maybe point to your website where you explain it?

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 I would contact transformation enzymes and ask for them to send you the study. It’s very long and complex and isn’t on the website
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