The weighted handles add resistance to your arms while allowing you to do intense cardio. The weighted ropes not only add resistance to your arms, but they also engage your upper back and your core as you maintain balance and coordination in your jumps. I know I feel it in my core and my in my back when I swing that 2lb rope around. It all depends on your goals. As what Karen said, it’s like apples and oranges.
If you want the benefit of a weighted jump rope system then you need to have the weight in the rope. They will work your whole body as well as cardio. Weighted handles are really just a waste of money. Your wrists and grip will fatigue before you get any cardio benefit from the jumping, or worse they’ll just teach you to jump with improper form, which could lead to injury.