A variety of genetic traits can make a person more likely to suffer from osteoarthritis, according to the Arthritis FoundationOff Site Icon (AF).
Though research is still being done to determine how osteoarthritis is specifically related to heredity and genetics, there is enough information available to connect genetics to people having a predisposition to the joint disease, according to the AF.
There is a rare genetic defect that can cause problems with the body’s ability to make collagen and another genetic condition that could lead to problems with how bones fit together, both of which could lead to osteoarthritis, according to the AF
There are various genetic traits that may contribute to development of osteoarthritis including the way some bones fit together or a rare defect in the production of collagen, which could trigger the disease for people as young as in their twenties. It is more common in people over 40, and more common and often more severe in women.
Osteoarthritis can be the result of genuine hereditary genetic diseases
and in this case we talk about secondary osteoarthritis
Haemophilia is a clotting disorder which is hereditary and results in bleeding in the skin, mucous membranes (gums, etc.) and also the joints. It is the repeated bleeding in the joints which causes the breakdown of cartilage and thus the onset of osteoarthritis.
Haemochromatosis is an inherited disease due to excess iron in the body. It manifests itself by discolouration of the skin, liver abnormalities and diabetes.
With regard to the joints, it results in severe osteoarthritis that affects mainly the hands and then other joints if left untreated.
Made possible by the sequencing of our genome, the search for genes involved in osteoarthritis is a necessary step in understanding the mechanisms of the disease and then, one day perhaps, in developing treatments that are able to repair the defective mechanisms.